CDKL5 Research Symposium 

8:00 – 9:00 am 

Registration

Breakfast in the Fairfax Dining Room 

9:00 – 9:15 am 

Welcome

David Frame, PharmD and Katheryn Elibri, DO

 International Foundation for CDKL5 Research, USA

9:15 – 10:00 am 

Current Understanding of CDKL5

10:00 – 10:45 am 

Updates from the International CDKL5 Database:

Improving our Understanding of the CDKL5 Phenotype

 Dr. Helen Leonard and Jenny Downs, PhD  

Telethon Kids Institute, Australia

10:45 – 11:15 am 

Control of CDKL5 levels in depolarized neurons

Charlotte Kilstrup-Nielsen, PhD

University of Insubria, Italy

11:15 - 11:30 am 

Break - coffee, tea, refreshments in the Rotunda

11:30 - 12:30 pm  

CDKL5 Mouse Models: characterization and molecular pathways

Judy Wang, PhD, University of Pennsylvania, USA

Maurizio Giustetto, PhD, University of Torino, Italy

12:30 - 1:30 pm

Lunch in the Fairfax Dining Room

1:30 - 2:15 pm

Modeling CDKL5 Disorder with iPS cells

Priscilla Negraes, PhD

University of California San Diego, USA 

2:15 - 2:45 pm 

GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells

Alessandra Renieri, MD 

University of Siena, Italy 

2:45 - 3:30 pm

The Epigenetics of CDKL5

3:30 - 3:45 pm

Break - coffee, tea, refreshments in the Rotunda 

3:45 - 4:00 pm

CDKL5 Clinical research and opportunities for collaboration among other rare epilepsies and disorders

Katheryn Elibri Frame, DO, IFCR

 4:00 - 4:45 pm

CDKL5 Centers of Excellence: The multidisciplinary approach to CDKL5 care, and exploring opportunities for translational research 

Walter Kaufmann, MD, Boston Children's Hospital

Tim Benke, MD, PhD, Children's Hospital Colorado

4:45 - 5:00 pm

CDKL5  Research:  Where do we go from here?

Closing Remarks

David Frame, PharmD