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"The locus coeruleus (LC) mediates behavioral flexibility"

Dr. Greta Vargova grew up in Slovakia where she pursued her undergraduate studies in molecular biology and PhD in neuroscience. In her doctoral research at the Slovak Academy of Sciences, Dr. Vargova co-developed, applied and characterized several types of adeno-associated viral vectors expressing human truncated tau and red fluorophore mCherry in equal ratio. These AAV vectors were developed to induce Alzheimer’s disease-like pathology in wildtype mice. She performed two-photon calcium imaging in awake mice to investigate the effects of developing neurodegeneration on cortical circuits. Dr. Vargova also had the opportunity to participate in long-term research at Cold Spring Harbor Laboratory, where she studied the role of cortical feedback projections in sensory perception.

Currently, Dr. Vargova is a third year postdoctoral researcher at UCR Riverside in the laboratory of Professor Hongdian Yang. She studies somatosensory perception and cognitive flexibility, for which they have developed a novel, tactile based rule-shift behavioral assay.

For this webinar, she is going to present their most recent publication, in which they show the link between locus coeruleus activity and behavioral flexibility.