Use of Ultra-Fast Scanning Triple Quadrupole Mass Spectrometers for Targeted Metabolomics Studies on Obesity and Metabolic Disease
--Ruth Gordillo, Ph.D. Assistant Professor at Touchstone Diabetes Center, UTSW Medical Center
The Touchstone Diabetes Center is devoted to the study of the cells and tissues that are either contributing to or are affected by diabetes and its related diseases. Research in the Touchstone Diabetes Center focuses on both basic and clinical aspects of Type 1 and Type 2 diabetes, and questions related to the impact of diabetes and obesity on cardiovascular disease outcome, renal disease and cancer progression. Liquid chromatography-tandem mass spectrometry targeted metabolomics is a fundamental tool in all of the areas of our research. Our analytical portfolio includes the exploration of sphingolipids and phospholipids, water soluble cellular metabolites, diastereomeric separations of carbohydrates and nucleotide sugars, and therapeutic antibodies.